Covishield vaccine remained effective against moderate-to-severe covid-19 even during the deadly surge of the highly transmissible Delta variant, according to a new study published in The Lancet Infectious Diseases journal.
Covishield had an efficacy of 63 percent in fully vaccinated people, while it was 81 percent effective against the moderate-to-severe disease, said the Lancet.
Conducted by Indian researchers, the Lancet study was meant to evaluate the real-world effectiveness of Covishield during the deadly outbreak of the Delta variant between April-May in India that crippled the health infrastructure.
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The researchers assessed the neutralizing activity and cellular immune responses against the variants in healthy vaccinated persons to understand the mechanisms of protection.
Researchers found that the Spike-specific T-cell responses were conserved against both the delta variant and wild-type SARS-CoV-2.