Liverpool's Premier League title bid suffered a devastating blow in a 2-0 defeat at Merseyside rivals Everton, while Manchester United spared Erik ten Hag's blushes with a 4-2 victory against lowly Sheffield United on Wednesday.
Jurgen Klopp's side were beaten at Goodison Park for the first time in 14 years in a brutal setback to their hopes of catching leaders Arsenal.
Jarrad Branthwaite put Everton ahead in the 27th minute as the defender prodded the ball under Liverpool keeper Alisson Becker via the post after the Reds made a hash of clearing a free-kick.
With Liverpool's Mohamed Salah once again struggling to convert chances to equalise, Everton striker Dominic Calvert-Lewin delivered the knockout punch with a 58th-minute header.
Second-placed Liverpool remain three points behind Arsenal, who have a vastly superior goal difference, with both sides having four games left.
Third-placed Manchester City, who visit Brighton on Saturday, will be crowned English champions for an unprecedented fourth successive season if they win their last six matches.
For the Red Devils, Fernandes bailed out Ten Hag with a penalty equaliser before the Portugal midfielder's long-range rocket put United in front with nine minutes left.
Rasmus Hojlund got United's fourth to ensure they could finally enjoy a first league win in five games since beating Everton on March 9.
It was a temporary reprieve for Ten Hag, who hopes to salvage sixth-placed United's dismal season by winning the FA Cup and finishing high enough to qualify for the Europa League.
Ten Hag endured stinging criticism after United stumbled into the FA Cup final with a spluttering penalty-shootout win after blowing a three-goal lead against second-tier Coventry on Sunday.