Last year's runners-up Nick Kyrgios withdrew from Wimbledon 2023 on the eve of the tournament due to a wrist injury.
The Australian, who was beaten in last year's final by Novak Djokovic, had earlier conceded there were "some question marks" over his participation.
In a statement posted on his social media accounts, Kyrgios wrote: "I'm really sad to say that I have to withdraw from Wimbledon this year.
"During my comeback, I experienced some pain in my wrist during Mallorca. As a precaution I had it scanned and it came back showing a torn ligament in my wrist.
Kyrgios had been scheduled to begin his campaign against Belgian former quarter-finalist David Goffin on Court One on Monday.
The 28-year-old has been unable to build on his sole grand slam final appearance after withdrawing from the Australian Open in January due to a knee injury which required surgery.
He had played only one match since, a defeat to Wu Yibing in Stuttgart last month, and admitted during his pre-tournament media rounds on Sunday that he was "almost dreading" his return.